Cognitive results in patients with meningioma who undergo surgery: individual changes over time and predictors of late cognitive operation
Netherlands study
Context : We know that patients with meningioma face cognitive deficits before and after the operation. We have examined the individual changes in cognitive performance over time and identified pre -operators of cognitive operation 12 months after the operation in a large sample of patients with meningioma.
Methods : Patients were subjected to a neuropsychological assessment ( neuropsychological assessment, NPA) using a computer neurocognitive evaluation ( CNS Vital SIGNS ) 1 day before (T0) and 3 (T3) and 12 (T12) months after the operation. The scores of patients corrected on the socio -demographic level for 7 cognitive areas were compared to the performance of a normative sample using Z tests on a sample and square KHI independence. Reliable change indices with correction for the effects of the practice have been calculated for each patient. Linear models with mixed effects have been used to identify preoperative performance predictors at T12.
Results : at T0, 261 patients were evaluated, and 229 and 82 patients were retests at T3 and T12, respectively. Patients showed altered cognitive performance before and after the operation, and although performance improved in the group level, cognitive scores remained significantly lower than those of the normative sample up to T12. At the individual level, performance remained stable in the majority of patients. Better preoperative performance, a younger age, a male sex and a higher level of education suggested better late cognitive performance.
Conclusions : Patients with meningioma face pre -and -persistent pre -and -persistent cognitive deficits. A preoperative NPA associated with socio -demographic characteristics can provide precious information on the late cognitive results of each patient with meningioma. These results can help inform patients and clinicians about late cognitive results at an early stage, and highlight the importance of a pre -surgical NPA and a timely cognitive rehabilitation.
KHI Square test: explanation here
Z test: explanation here
Cognitive results in patients with meningioma who undergo surgery: individual changes over time and predictors of late cognitive operation
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