Summary
Context : Some patients are experiencing a lasting drop in their quality of life as a result of a resection of meningioma, but the associated factors are not well understood.
Objective : to determine whether the low -term quality of life reductions (in particular adaptive functioning disorders) after a resection of meningioma are associated with specific personality disorders which often develop with lesions of the Ventrométal Cortex (VMPFC).
Methods : We studied 38 patients who underwent a resection of meningioma, 18 of which had VMPFC lesions and 20 lesions elsewhere (non -VMPFC). In total, 30 characteristics of the personality were evaluated by the spouse or the family, and a neuropsychologist evaluated the blind operation an average of 3.8 years after resection. Relevant personality disorders have been defined by a preliminary process: the presence of “joint personality disorders” required specific disturbances in at least 2 of the 4 types of disorders: executive disorders, disturbed social behavior, emotional and hypoemitivity dysregulation.
Results : Fourteen patients had adaptive functioning disorders: 12 had VMPFC lesions and 2 of non -VMPFC lesions. Fourteen patients had joint personality disorders, and 12 of them had an altered adaptive operation. On the other hand, among the 24 patients who did not have joint personality disorders, only 2 had an altered adaptive operation. Mediation analysis has shown that the association between VMPFC lesions and the impairment of adaptive functioning was due to the negative impact of personality disorders acquired on adaptive operation.
Conclusion : Meningiomas of the basis of the previous skull and resection surgery can cause specific personality disorders which are strongly associated with an alteration of adaptive functioning during long -term monitoring. These patients can benefit from early advice on potential personality changes and their implications for adaptive functioning.
Keywords : brain tumor; Frontal lobe; Iowa personality change scales; Personality change; Ventromedial prefrontal cortex.
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