Summary
Objective : meningiomas have a female predilection, which is even stronger for spinal meningomes than for intracranial meningiomas. The relationship between meningiomas and endogenous or exogenous sex hormones such as cyproterone acetate (CPA) is well documented, but their underlying mechanism remains unknown. Clarification of the expression profile of hormonal receptors by meningiomes would help us to better understand their hormonal sensitivity.
Methods : We have used biopuces and immunohistochemistry to determine the status of receptors of the 3 main sex hormones: androgen (AR), estrogen and progesterone (PR) in 30 intracranial meningiomas, 30 spinal meningiomas and 30 meningiomas developed on cyproterone acetate (CPA).
Results : The androgen status (AR) was positive in 73% of the meningomes of the intracranial group, 87% of the meningiomas of the cyproterone acetate group (CPA) and in all the meningiomas of the spinal group. Estrogenic status was positive in only 7 % of meningiomas of the intracranial group and in only 3 % of the meningiomas of the Cyproterone Acetate Group (CPA), but in 30 % of the spinal groupiomas of the spinal group. Progesterone status (PR) was positive in 90 % of the meningiomas of the intracranial group, in 97 % of the meningiomas of the Cyproterone Acetate group (CPA) and in 87 % of the meningiomas of the spinal group. These specific statutes of hormonal receptors based on the immunoreactive score have been reflected on the coloring intensities. In addition, the expression of androgen (AR) and progesterone (PR) was correlated in each group.
Conclusions : Our study shows that intracranial meningiomas, spinal meningomes and meningiomas developed on cyproterone acetate (CPA) express models of specific hormonal receptors. This result invites the scientific community to examine the potential role of androgen (AR) in the imbalance of sex-rat of meningiomas.
Keywords : androgens receiver; Cyproterone acetate; Estrogen receptor; Meningioma; Progesterone receiver.
Made by French doctors and surgeons: Sylvain Portet, Tania Banor, Jonathan Bousquet, Adrien Simonneau, Marie Flores, Pierre Ingrand, Serge Milin, Lucie Karayan-Tapon, Benoit Bataille
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