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Research support on meningiomas

We readily relay a participatory campaign in order to advance research on hormonal-dependent meningiomes.

Meningiomas are the most frequent intracranial tumors. Each year, around 5,000 to 6000 patients are made of meningiomas in France .

These are so-called hormone-sensitive tumors, which explains that the prescription of high-dose progestogen agonists like Androcur® leads to a development of these tumors.

The project seeks to understand how Androcur® leads to the development of these meningiomas, and why they specifically present mutation on the Pik3CA gene, a gene also involved in other hormone-dependent cancers such as breast or endometrium cancer.

By studying the mechanisms of progesterone actions on meningiomas, and by establishing the molecular identity card of these tumors, we hope to identify new therapeutic avenues to offer patients carrying these tumors.

This campaign is the work of Nathalie Cauvi, daughter of Roselyne Cauvi, suffering from a recurrent and aggressive grade III meningiom .
She understands:
- A YouTube channel : https://www.youtube.com/channel/ucgxftf7dqdjcorfxfwdejug
- A first video shot at the ICM : https://www.youtube.com/watch?v=ctooe8iixvi
- A Facebook page : https://www.facebook.com/soutien.meningiome
who will be updated regularly with new content: images, video, donors names, etc.
-Okpal collection:  https://www.okpal.com/de-nouvelles-pistes--herapeutiques-conre-les-me/#/
- An A4 flyer to relay by email and to print (a QRCode redirects to the Okpal collection) available in PJ and on this Google Drive link with all other documents: https://drive.google.com/drive/folders/1nvaweuawip_vno0irdclf5lg3b1?usp=Sharing
-5,000 A5 flyers Recto-verso on icy paper

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Regulatory aspect:
tumor samples come from the PRB of the APHP PSL. All patients gave written consent to the use of their biological samples.

Organization:
The project is led by Matthieu Peyre in the team of Pr Michel Kalamarides. He is the subject of a current science thesis of Julien Boetto , within the research team "Genetic and development of brain tumors, at the Brain Institute (CNRS UMR 7225, Inserm 1127, Sorbonne University) . The project is already well advanced since the majority of DNA sequencing as well as RNA sequencing have already been carried out.

Researchers: 

  • Michel Kalamarides: professor in neurosurgery, researcher
  • Matthieu Peyre: Doctor of neurosurgery, researcher
  • Julien Boetto: Doctor of neurosurgery, researcher

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Financial step:
finalize the total budget of 40,000 euros thanks to a call for crowdfunding on the OKPAL platform (20,000 euros) at the end of 2021 in order to be able to finalize the study.

Realization of investigations: First quarter 2022.

Analysis of results and writing a scientific article: end of 2022.

Expenses: 

  • Finalization of DNA (Whole Exomencing): 9,000 euros sequencing sequencing
  • Méningiomes methylation study: 9,000 euros
  • Immuno-histochemical validations studies of the markers discovered: 2,000 euros

To participate in fundraising:
https://www.okpal.com/de-nouvelles-pistes--herapeutiques-conre-les-me/#/

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