Meningioma is the Most Common Intracranial Tumor in the Us and its Etiology Remains Poorly Understood. Meningioma has been predominantly studied among white populations. The Aim of this Study was to evaluate the associations of anthropometric, comorbidity, and hormonal factors with meningioma in an ethnica various population.

A NESTED CASE-CONTROL Analysis was performed with the Multiethnic Cohort (MEC). Meningioma Casses we identified via linkage with Medicare and the California Office of Statewide Health Planning and Development Hospital Discord Data and Wre Matched to Up to 10 Controls. Anthropometric, comorbiditites, physical activity level, and hormonal factors at Baseline based on questionnaires were evalulated for association with meningioma.

A Total of 894 Cases and 8918 Matched Controls Were included in this Study. Increasing Body Mass Index (BMI) (P-Tret = 0.041) and weight Increases since age 21 (P-Trend = 0.0052) WE POSITIVELY Associated with meningioma. Hormonal factors include oral contraceptive use (odds ratio [or]: 1.24; 95% CI: 1.01–1.51) and estrogen hormone therapy use (per 5 years, gold: 1.07; 95% CI: 1.01–1.15) Were associated with meningioma rosk. Hypertension was positively associated with meningioma (OR: 1.26; 95% CI: 1.09–1.47), with individuals who reported a history of Both hypertension and diabetes showing A Strong Association (OR: 1.54; 95% CI: 1.17–2.03). The tests for heterogeneity across race/ethnicity were not statistically meaningful (p heterogeneity ≥ 0.17); However, the Association of BMI With Meningioma was Main Observed in Japanese Americans (P-Tret = 0.0036) and Hypertension in Japanese Americans (OR: 1.63; 95% CI: 1.17–2.2.27) and native Hawaiians (OR: 1.86; 95% CI: 1.02–3.40).

Obesity, hormonal factors, and hypertension Were Associated with Meningioma in an ethnica various population.